Two sample MR report
HLA-DQA1_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | -0.0055993 | 0.0612654 | 0.9280880 |
| Weighted median | 22 | 0.0982587 | 0.0085095 | 0.0000000 |
| Inverse variance weighted | 22 | 0.0925888 | 0.0057803 | 0.0000000 |
| Simple mode | 22 | 0.1076233 | 0.0190031 | 0.0000127 |
| Weighted mode | 22 | 0.1062341 | 0.0192171 | 0.0000174 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 21.97713 | 20 | 0.3417530 |
| Inverse variance weighted | 24.82314 | 21 | 0.2549052 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0539878 | 0.0335465 | 0.1232135 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003586 | 8e-07 | TRUE | 0.0850195 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
